2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P4333
    Boc-Glu(OBzl)-Gly-Arg-AMC 73554-94-6 98%
    Boc-Glu(OBzl)-Gly-Arg-AMC is a fluorogenic substrate for factors IXa and XIIa. The cleavage of the amide bond between arginine and the methylcoumarin amide group releases fluorescent 7-Amino-4-methylcoumarin (HY-D0027).
    Boc-Glu(OBzl)-Gly-Arg-AMC
  • HY-P4420
    H-Lys-Trp-OH 50674-18-5 98%
    H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with an IC50 of 7.8 μM.
    H-Lys-Trp-OH
  • HY-P4475
    Sar-Pro-Arg-pNA 77695-30-8 98%
    Sar-Pro-Arg-pNA is a chromogenic substrate of α-thrombin. Sar-Pro-Arg-pNA can be used to test α-thrombin activity.
    Sar-Pro-Arg-pNA
  • HY-P4560
    H-Pro-Phe-OH 13589-02-1 98%
    H-Pro-Phe-OH is a dipeptide containing proline and phenylalanine, which can serve as a substrate for prolinase. H-Pro-Phe-OH can also be used for polypeptide synthesis, where phenylalanine is an aromatic amino acid that can inhibit the activity of Angiotensin-converting enzyme (ACE, HY-P2983).
    H-Pro-Phe-OH
  • HY-P4641
    H-Trp-Phe-OH 6686-02-8 98%
    H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice.
    H-Trp-Phe-OH
  • HY-P4650
    Tyrosylhistidine 3788-44-1 98%
    Tyrosylhistidine is a dipeptide consisting of tyrosine and histidine (Tyr-His). Tyrosylhistidine is an orally active antihypertensive peptide. Tyrosylhistidine reduces blood pressure in mice in a model of spontaneous hypertension.
    Tyrosylhistidine
  • HY-P4721
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 131791-98-5 98%
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM.
    Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
  • HY-P4766
    Adrenomedullin (porcine) 912862-96-5 98%
    Adrenomedullin (porcine) is a peptide that regulates vasodilation. Adrenomedullin (porcine) induces endothelium-dependent relaxation in rat aorta with IC50 value of 2.4 nM. Adrenomedullin (porcine) induces endothelium-independent relaxation of porcine coronary arteries with an IC50 of 27.6 nM.
    Adrenomedullin (porcine)
  • HY-P4893
    (Gln22,Asn23)-Amyloid β-Protein (1-40) 374796-75-5 98%
    (Gln22,Asn23)-Amyloid β-Protein (1-40) is a peptide. (Gln22,Asn23)-Amyloid β-Protein (1-40) can be used for the research of Cerebral Amyloid Angiopathy Mutations.
    (Gln22,Asn23)-Amyloid β-Protein (1-40)
  • HY-P4898
    Anthopleurin-A 98%
    Anthopleurin-A is a soidum channel toxin. Anthopleurin-A is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A can be isolated from the sea anemone.
    Anthopleurin-A
  • HY-P4908
    S-(1,2-Dicarboxyethyl)glutathione 1115-52-2 98%
    S-(1,2-Dicarboxyethyl)glutathione is a peptide that inhibits blood coagulation and platelet aggregation.
    S-(1,2-Dicarboxyethyl)glutathione
  • HY-P4911
    SDF-1α (human) 1268129-65-2 98%
    SDF-1α (human) is a mononuclear cells chemoattractant that can bind to CXCR4. SDF-1α plays a central role in stem cell homing, retention, survival, proliferation, cardiomyocyte repair, angiogenesis and ventricular remodelling following myocardial infarction. SDF-1α (human) can be used in cardiovascular disease research.
    SDF-1α (human)
  • HY-P4994
    Val9-Oxytocin 1021701-88-1 98%
    Val9-Oxytocin is a full antagonist of vasopressin (V1a) receptor. Val9-Oxytocin is an analog of Oxytocin (HY-17571A) in which changing Gly9 to Val9.
    Val9-Oxytocin
  • HY-P5006
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin 176714-12-8 98%
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific antagonist of vasopressin V1a receptor, with a pA2 of 6.71.
    (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
  • HY-P5007
    Copeptin (human) 78362-34-2 98%
    Copeptin (human) is a diagnostic and prognostic biomarker for cardiovascular disease (CVD). Copeptin (human) is also the carboxyl terminus of the arginine vasopressin (AVP) precursor peptide. Copeptin (human) can be used in the study of cardiovascular disease.
    Copeptin (human)
  • HY-P5010
    (D-Arg8)-Inotocin 745816-74-4 98%
    (D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R.
    (D-Arg8)-Inotocin
  • HY-P5027
    Cbz-Lys-Arg-pNA 108318-37-2 98%
    Cbz-Lys-Arg-pNA is a peptide substrate containing pNA as the chromogenic group. Cbz-Lys-Arg-pNA is widely used in enzymatic analysis, including thrombin, plasmin, factor Xa and Kallikrein.
    Cbz-Lys-Arg-pNA
  • HY-P5059
    Dendroaspis Natriuretic Peptide 255721-52-9 98%
    Dendroaspis Natriuretic Peptide is a vasodilator peptide that can be isolated from animal venom.
    Dendroaspis Natriuretic Peptide
  • HY-P5121
    γ-Fibrinogen 377-395 957792-67-5 98%
    γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.
    γ-Fibrinogen 377-395
  • HY-P5130
    Big endothelin-1 (rat 1-39) 98%
    Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice.
    Big endothelin-1 (rat 1-39)
Cat. No. Product Name / Synonyms Application Reactivity